DNA delivery via cationic solid lipid nanoparticles (SLNs)
نویسندگان
چکیده
منابع مشابه
Ternary nanoparticles composed of cationic solid lipid nanoparticles, protamine, and DNA for gene delivery
BACKGROUND The objective of this research was to design an effective gene delivery system composed of cationic solid lipid nanoparticles (SLNs), protamine, and Deoxyribonucleic acid DNA. METHODS Cationic SLNs were prepared using an aqueous solvent diffusion method with octadecylamine as the cationic lipid material. First, protamine was combined with DNA to form binary protamine/DNA nanopartic...
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Risperidone (RISP) is an antipsychotic agent and has low water solubility and nontargeted delivery results in numerous side effects. Hence, an attempt was made to develop SLNs hydrogel for intranasal delivery of RISP to achieve maximum bioavailability and reduction of side effects. RISP loaded SLNs composed of 1.65% (w/v) lipid mass were produced by high shear homogenization (HSH) coupled ultra...
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To enhance the intracellular delivery potential of plasmid DNA using nonviral vectors, we used polybutyl cyanoacrylate (PBCA) and chitosan to prepare PBCA nanoparticles (NPs) by emulsion polymerization and prepared NP/DNA complexes through the complex coacervation of nanoparticles with the DNA. The object of our work is to evaluate the characterization and transfection efficiency of PBCA-NPs. T...
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1 Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal; 2 Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Vila Real, Portugal, 3 Department of Biology and Environment, University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal; 4 Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcel...
متن کاملCell transfection using layer-by-layer (LbL) coated calixarene-based solid lipid nanoparticles (SLNs).
Polycationic calixarene-based solid lipid nanoparticles (SLNs) have been loaded at their surface with DNA and chitosan and studied for their ability to transfect mammalian cells.
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2013.02.011